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The Bloody Crisis !!INSTALL!!

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All types are needed now, especially types O positive and O negative, as well as platelet donations, to help reverse this national blood crisis. If there is not an immediate opportunity available to donate, donors are asked to make an appointment in the days and weeks ahead to ensure the Red Cross can replenish and maintain a sufficient blood supply.

In January 2022, the American Red Cross declared its first-ever national blood crisis due to a severe blood shortage resulting from complications of the COVID-19 pandemic. During that time, hospitals and physicians were forced to make difficult decisions about how to best use the limited available supply of donated blood.

BLOOD DONORS HELP OVERCOME CRISIS After the Red Cross issued the national blood crisis alert, there was a strong response from the public with many generous individuals rolling up a sleeve to donate to help those in need, like Kristen. Thanks to the support of countless blood donors, the blood supply slowly recovered to sufficient levels by spring 2022, ensuring patients could receive the medical care they needed.

The organization said on Tuesday that the "national blood crisis" is threatening patient care and forcing doctors to make tough choices about who is able to receive blood transfusions, and it's urging people to donate.

Since the beginning of the pandemic, fewer people have donated blood. That's led to a shortage that the American Red Cross is now calling a blood crisis. It's especially a problem in rural parts of the country. Montana Public Radio's Aaron Bolton has more.

BOLTON: That's why, for the first time, the Red Cross has declared a blood crisis. The Blood Centers of America and others also say they are grappling with a major supply shortage. Claudia Cohn is the chief medical officer for the Association for the Advancement of Blood and Biotherapies. Cohn says the supply issue is really bad nationwide.

Pain is the most common complication of SCD, and the top reason that people with SCD go to the emergency department or hospital. Sickled cells traveling through small blood vessels can get stuck and block blood flow throughout the body, causing pain. A pain crisis (vaso-occlusive episode or VOE) can start suddenly, be mild to severe, and can last for any length of time. Pain can occur in any part of the body, but commonly occurs in the hands, feet, chest, and back.

Blast crisis (BC) remains the major challenge in the management of chronic myeloid leukemia (CML). It is now generally accepted that BC is the consequence of continued BCR-ABL activity leading to genetic instability, DNA damage, and impaired DNA repair. Most patients with BC carry multiple mutations, and up to 80% show additional chromosomal aberrations in a nonrandom pattern. Treatment with tyrosine kinase inhibitors has improved survival in BC modestly, but most long-term survivors are those who have been transplanted. Patients in BC should be treated with a tyrosine kinase inhibitor according to mutation profile, with or without chemotherapy, with the goal of achieving a second chronic phase and proceeding to allogeneic stem cell transplantation as quickly as possible. Although long-term remissions are rare, allogeneic stem cell transplantation provides the best chance of a cure in BC. Investigational agents are not likely to provide an alternative in the near future. In view of these limited options, prevention of BC by a rigorous and early elimination of BCR-ABL is recommended. Early response indicators should be used to select patients for alternative therapies and early transplantation. Every attempt should be made to reduce or eliminate BCR-ABL consistent with good patient care as far as possible.

Blast crisis (BC) is the major remaining challenge in the management of chronic myeloid leukemia (CML). The introduction of an inhibitor targeted at the BCR-ABL tyrosine kinase (imatinib) has fundamentally changed treatment of CML.1 BCR-ABL expression can be reduced by imatinib to ve


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