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Hyperplasia


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Hyperplasia


Endometrial hyperplasia is rare. It affects approximately 133 out of 100,000 people AFAB. It most commonly occurs in people who are transitioning to or just completed menopause (when you stop getting a menstrual period).


A lot of these symptoms are common in people transitioning to menopause. Transitioning to menopause often means erratic periods or skipping periods and irregular bleeding. Talk to your healthcare provider about your symptoms so they can determine if checking for endometrial hyperplasia is necessary.


A hysterectomy is usually not necessary for treating endometrial hyperplasia. Most people respond well to progestin treatment. If your risk for uterine cancer is high and your healthcare provider diagnoses you with complex atypical endometrial hyperplasia, hysterectomy may be a possible treatment option.


Endometrial hyperplasia responds well to progestin treatments. Atypical endometrial hyperplasia can lead to endometrial or uterine cancer. Your healthcare provider may recommend more frequent ultrasound exams, biopsies or a hysterectomy to eliminate the chances of it turning into cancer. Your provider will base this recommendation on your diagnosis and health history.


No, not always. The risk of developing cancer ranges anywhere from 8% to 30% depending on the type of endometrial hyperplasia you have. Only certain types of endometrial hyperplasia lead to cancer. Your healthcare provider can discuss the type you have and recommend the best treatment based on your health history and your overall risk for cancer.


Endometrial hyperplasia tends to occur in people who are transitioning to menopause or who have gone through menopause. The average age of menopause is 51 years old. People between 50 and 60 are most likely to develop endometrial hyperplasia.


Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. These symptoms can be uncomfortable and disruptive. Many people find relief through progestin hormone treatments. People who have atypical endometrial hyperplasia have a higher risk of developing uterine cancer. A hysterectomy stops symptoms and eliminates cancer risk. Talk to your healthcare provider about the best treatment for you.


Hyperplasia is an overgrowth of the cells that line the lobules (milk-producing glands) or ducts (small tubes) inside the breast. It is not cancer, but some types of hyperplasia are linked with a higher risk of developing breast cancer (see below).


McEvoy MP, Coopey SB, Mazzola E, et al. Breast cancer risk and follow-up recommendations for young women diagnosed with atypical hyperplasia and lobular carcinoma in situ (LCIS). Ann Surg Oncol. 2015;22:3346-3349.


Hyperplasia is a common preneoplastic response to stimulus.[6] Microscopically, cells resemble normal cells but are increased in numbers. Sometimes cells may also be increased in size (hypertrophy).[7] Hyperplasia is different from hypertrophy in that the adaptive cell change in hypertrophy is an increase in the size of cells, whereas hyperplasia involves an increase in the number of cells.[8]


Perhaps the most interesting and potent[editorializing] effect insulin-like growth factor 1 (IGF) has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells.[11] By contrast, hypertrophy is what occurs, for example, to skeletal muscle cells during weight training and is simply an increase in the size of the cells.[12] With IGF use, one is able to cause hyperplasia which actually increases the number of muscle cells present in the tissue.[13] Weight training enables these new cells to mature in size and strength. It is theorized that hyperplasia may also be induced through specific power output training for athletic performance, thus increasing the number of muscle fibers instead of increasing the size of a single fiber.[14]


Hyperplasia is considered to be a physiological (normal) response to a specific stimulus, and the cells of a hyperplastic growth remain subjec




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